Original videos documenting Curt I. Civins's discovery of the cell surface protein that makes stem cell selection possible; and interviews with Kenneth Kinsler and Bert Vogelstein.
In the 1970s when Civin began stem cell research, little was known about progeniters, the cells of all other blood lineages. Civin thought that stem cells had their own identifying surface proteins. To test this, he immunized mice with leukemia cells, some of which he supposed might have that peculiar protein and then harvested the resulting immunoglobulins and reproduced them as monoclonal antibodies. In 1981, Civin discovered an antibody that bound to 1% of marrow cells.
Related Archival Materials:
Prototype of stem cell selector instrument housed in Division of Science and Medicine and Society (now Division of Medicine and Science).
Created by the Jerome and Dorothy Lemelson Center for the Study of Invention and Innovation, National Museum of American History, 1997.
Collection is open for research but the original videos are stored off-site and special arrangements must be made to work with it. Contact the Archives Center for information at firstname.lastname@example.org or 202-633-3270.
Collection items available for reproduction, but the Archives Center makes no guarantees concerning copyright restrictions. Other intellectual property rights may apply. Archives Center cost-recovery and use fees may apply when requesting reproductions. Signed releases in file.