NZPWHS copy purchased with funds from the S. Dillon Ripley Endowment.
Contents:
Machine generated contents note: 1. General neuropathology -- 1.1. Principles of neuroanatomy for diagnostic neuropathologists -- 1.1.1. Anatomical orientation by using the ventricular system -- 1.1.2. Major anatomical regions of interest -- 1.1.3. Histological neuroanatomy -- 1.2. Neuropathological techniques -- 1.2.1. Necropsy techniques -- 1.2.2. Brain sectioning, macroscopic inspection and sampling for histology -- 1.3. Basic tissue reaction patterns -- 1.3.1. Reactions of neurons to injury -- 1.3.2. Oligodendrocytes -- 1.3.3. Astrocytes -- 1.3.4. Microglia/macrophages -- 1.3.5. CSF spaces -- 1.3.6. Blood vessels -- 1.3.7. Disturbance of water balance: edema -- 1.3.8. Artifacts, postmortem degeneration, pseudolesions and old age -- 1.4. Recognizing major lesion patterns -- 1.4.1. The major lesion patterns -- 1.4.2. Lesion distribution pattern -- 1.4.3. Classification of neurological diseases -- 1.4.4. General strategy -- 1.5. Neuropathology in the clinics: magnetic resonance imaging (MRI)
Contents note continued: 1.5.1. Basic MRI physics -- 1.5.2. Principles of interpretation -- Further reading -- Neuropathology general -- Neurology/functional neuroanatomy -- Neuroanatomy -- Techniques for PNS and muscle -- Basic tissue reaction patterns -- Edema -- Artifacts, pseudolesions, old age -- Magnetic resonance imaging -- 2. Vascular disorders -- 2.1. Pathophysiology of ischemia -- 2.2. General strategy for diagnosing vascular lesions -- 2.3.Common vascular lesions -- 2.3.1. Vascular lesions of the brain -- 2.3.2. Vascular lesions of the spinal cord -- 2.3.3. Ischemia in the peripheral nervous system and muscles -- Further reading -- Cerebral infarcts -- Hemorrhage -- Hypertensive encehalopathy -- Fibrocartilagenous emboli -- Aortic thrombosis -- 3. Inflammatory diseases -- 3.1. Pathophysiology of inflammation -- 3.1.1. Entry and effect of infectious agents in the nervous system -- 3.1.2. Immune reaction of the host against the infectious agent in the CNS
Contents note continued: 3.1.3. Morphological aspects of the immune response -- 3.2. General strategy for diagnosis of inflammatory lesions -- 3.2.1. Recognizing major inflammatory reaction patterns -- 3.2.2. Determining the distribution pattern of the lesions -- 3.2.3. Specific features -- 3.3.Common CNS infections -- 3.3.1. Neurotropic viral infections -- 3.3.2. Viral granulomatous inflammation -- 3.3.3. Viral vasculitis -- 3.3.4. Viral leukoencephalitis -- 3.3.5. Bacterial infections -- 3.3.6. Mycotic and algal infections -- 3.3.7. Protozoal infections -- 3.3.8. Helminth infections -- 3.4. Non-infectious and immune-mediated inflammatory lesions -- 3.4.1. Definition -- 3.4.2. Neurological diseases assumed to be immune-mediated -- Further reading -- General -- Neurotropic viral infections -- Viral granulomatous infections -- Viral vasculitis -- Demyelinating viral infections -- Bacterial infections -- Fungal infections -- Protozoal infections -- Helminth infections
Contents note continued: Non-infectious and Immune-mediated inflammatory disorders -- 4. Trauma -- 4.1. Pathophysiology of CNS trauma -- 4.1.1. Pathogenesis of brain trauma -- 4.1.2. Pathogenesis of spinal cord trauma -- 4.2. General strategy for diagnosis of traumatic CNS lesions -- 4.3. Traumatic nervous system diseases -- 4.3.1. Trauma of the brain -- 4.3.2. Traumatic spinal cord lesions -- 4.3.3. Trauma in the peripheral nervous system -- Further reading -- Pathophysiology of CNS trauma -- Brain trauma -- Intervertebral disc disease -- Spinal malformations -- Wobbler syndrome -- Other causes of cord compression -- Cauda equina syndrome -- 5. Congenital malformations -- 5.1. Pathophysiology -- 5.1.1. Ontogeny of the CNS -- 5.1.2. Etiology -- 5.2. General strategy for diagnosing anomalies of the CNS -- 5.3.Common malformations -- 5.3.1. Neural tube closure defects -- 5.3.2. Defects of forebrain induction -- 5.3.3. Neuronal migration disorders and sulcation defects
Contents note continued: 5.3.4. Disorders of proliferation or size -- 5.3.5. Encephaloclastic defects -- 5.3.6. Malformations in the caudal fossa and spinal cord -- 5.3.7. Congenital hydrocephalus and other anomalies of CSF pathways -- Further reading -- Neural tube closure defects -- Defects of forebrain induction -- Neuronal migration disorders and sulcation defects -- Encephaloclastic defects -- Cerebellar hypoplasia -- Dandy Walker syndrome -- Chiari malformation, Syringomyelia -- Hydrocephalus -- Arachnoidal and ependymal cysts -- 6. Metabolic-toxic diseases -- 6.1. General strategy for diagnosis of metabolic-toxic lesions -- 6.1.1. The major patterns -- 6.1.2. Further differential diagnosis -- 6.2. Encephalomalacias/myelomalacias -- 6.2.1. Polioencephalomalacia (PE) or cerebrocortical necrosis (CCN) -- 6.2.2. Polioencephalomalacia of subcortical structures and brainstem -- 6.2.3. Poliomyelomalacia -- 6.2.4. Leukoencephalomalacias
Contents note continued: 6.2.5. Encephalomalacias involving both gray and white matter -- 6.3. Acquired metabolic-toxic selective lesions -- 6.3.1. Neuronal degeneration -- 6.3.2. Axonal degeneration -- 6.3.3. Myelin degeneration -- 6.4. Spongy degeneration -- 6.5. Metabolic-toxic lesions of the peripheral nervous system (PNS) and skeletal muscle -- 6.5.1. Metabolic-toxic neuropathies -- 6.5.2. Metabolic-toxic myopathies -- Further reading -- General -- Polioencephalomalacia large animals -- Polioencephalomalacia in small animals -- Hippocampal necrosis and sclerosis -- Subcortical and brainstem encephalomalacias -- Selenium poisoning -- Equine leukomalacia -- Enterotoxemia -- CO poisoning -- Metabolic toxic neuronal degenerations -- Grass sickness -- Acquired lysosomal storage diseases -- Metabolic-toxic axonal degenerations -- Irradiated feed-induced myelinopathy in cats -- Toxic spongy degenerations -- Hepatic encephalopathy -- Toxic peripheral neuropathies
Contents note continued: Metabolic peripheral neuropathies -- Matabolic-toxic myopathies -- 7. Neoplasia -- 7.1. General strategy for diagnosis of neoplastic lesions -- 7.1.1. Clinic and diagnostic imaging -- 7.1.2. Interpretation of gross findings -- 7.1.3. Diagnosis -- 7.1.4. Grading -- 7.2. Tumors of neuroepithelial origin -- 7.2.1. Astrocytomas -- 7.2.2. Oligodendroglioma -- 7.2.3. Mixed gliomas (oligoastrocytomas) -- 7.2.4. Ependymoma -- 7.2.5. Choroid plexus tumors (papillomas and carcinomas) -- 7.2.6. Neuronal and mixed neuronalglial tumors -- 7.2.7. Embryonal tumors -- 7.3. Tumors of cranial and spinal nerves -- 7.3.1. Benign PNST -- 7.3.2. Malignant peripheral nerve sheath tumors (MPNST) -- 7.4. Tumors of the meninges -- 7.4.1. Meningioma -- 7.4.2. Granular cell tumor -- 7.4.3. Mesenchymal tumors -- 7.5. Lymphomas and hematopoietic tumors -- 7.5.1. Primary T and B cell lymphomas -- 7.5.2. Intravascular lymphoma -- 7.5.3. Metastatic lymphoma -- 7.5.4. Primary CNS histiocytic sarcoma
Contents note continued: 7.6. Germ cell tumors -- 7.6.1. Germinoma -- 7.6.2. Teratoma -- 7.7. Embryonal tumors of non-neuroepithelial origin -- 7.7.1. Thoracolumbar spinal cord tumor (ectopic nephroblastoma) -- 7.8. Secondary or metastatic tumors -- Further reading -- General -- Glial tumors -- Choroid plexus tumors -- Neuronal tumors -- Embryonal tumors -- PNS tumors -- Meningiomas -- Granular cell tumor -- Mesenchymal tumors -- Lymphomas and hemapoetic tumors -- Germ cell rumors -- Nephroblastoma -- Metastatic tumors -- 8. Degenerative diseases -- 8.1. General strategy for differential diagnosis of degenerative lesions -- 8.1.1. Recognizing the major patterns -- 8.1.2. Further analysis -- 8.1.3. Diagnosis -- 8.2. Degeneration of neurons -- 8.2.1. General aspects -- 8.2.2. Motor neuron diseases -- 8.2.3. Cerebellar degenerations -- 8.2.4. Other neuronal degenerations -- 8.3. Axonal degenerations -- 8.3.1. Wallerian-like degenerative axonopathies
Contents note continued: 8.3.2. Axonopathies with prominent axonal swelling -- 8.4. Myelin disorders -- 8.4.1. Leukodystrophies -- 8.4.2. Myelin dysgenesis -- 8.5. Storage diseases -- 8.5.1. Lysosomal storage diseases -- 8.5.2. Neuronal ceroid lipofucsinoses (NCL) -- 8.5.3. Lafora's disease -- 8.5.4. Acquired lysosomal storage diseases -- 8.6. Spongiform encephalopathies -- 8.6.1. Transmissible degenerative diseases -- 8.6.2. Neuropathology of TSE -- 8.6.3. TSEs in domestic animals -- 8.7. Spongy degenerations -- 8.7.1. Definition and general morphological features -- 8.7.2. Spongy degeneration in branched-chain organic acidurias -- 8.7.3. Spongy degenerations of other causes -- 8.8. Selective symmetrical encephalomalacias (SSE) -- 8.8.1. General morphological features -- 8.8.2. Mitochondrial encephalopathies in people and similar lesions in animals -- 8.9. Degenerative diseases of the peripheral nervous system and muscle -- 8.9.1. Degenerative polyneuropathies -- 8.9.2. Degenerative myopathies
Contents note continued: Further reading -- Motor neuron diseases -- Cerebellar degenerations -- Other neuronal degenerations -- Alzheimer disease -- Wallerian-like axonal degenerations -- Degenerative myelopathy in old dogs -- Wallerian-like degeneration in large animals -- Neuroaxonal dystrophy -- Leukodystrophies -- Dysmyelination -- Lysosomal storage diseases -- Spongiform encephalopathies -- Spongy degenerations -- Selective symmetrical encephalomalacias -- Degenerative diseases of the PNS and muscles
