Original videos documenting Curt I. Civins's discovery of the cell surface protein that makes stem cell selection possible; and interviews with Kenneth Kinsler and Bert Vogelstein.
In the 1970s when Civin began stem cell research, little was known about progeniters, the cells of all other blood lineages. Civin thought that stem cells had their own identifying surface proteins. To test this, he immunized mice with leukemia cells, some of which he supposed might have that peculiar protein and then harvested the resulting immunoglobulins and reproduced them as monoclonal antibodies. In 1981, Civin discovered an antibody that bound to 1% of marrow cells.
Related Archival Materials:
Prototype of stem cell selector instrument housed in Division of Science and Medicine and Society.
National Museum of American History, Smithsonian Institution, Dept. of History.,Lemelson Center for the Study of Invention and Innovation, Room 1016, MRC 604, 12th & Constitution Ave., N.W., Washington, D.C. 20560.,Made for NMAH.,1997.3168.
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